Protein Degraders & Molecular Glues Icon

Cambridge Healthtech Institute’s 6th Annual

Protein Degraders & Molecular Glues - Part 2

Emerging Degrader Modalities and Screening Strategies

April 12-13, 2023


The ubiquitin-proteasome, lysosome, and autophagy systems are all well-controlled, selective pathways for intracellular protein degradation and turnover, and act as key regulators in cancer, CNS, and other diseases. However, a new generation of inhibitors and activators are now being developed to disrupt protein-protein interactions and hijack these systems for targeted protein degradation or stabilization. Using this strategy, Proteolysis-targeting chimeras (PROTACs), molecular glues, and other small molecule modalities are being used to seek out previously “undruggable” targets for therapeutic intervention. However, challenges do exist in terms of specificity, stability, biodistribution, and penetration of these degrader molecules. This two-part conference on Protein Degraders & Molecular Glues brings together experts in the field to discuss important issues underlying the use of targeted protein degradation as a new therapeutic approach.


Coverage will likely include:


  • Update on emerging PROTACs, molecular glues, and new degrader modalities
  • Design, characterization, and optimization of protein degraders and glues
  • Finding new ligases for targeted degradation
  • New screening approaches to identify and optimize novel degraders
  • Understanding challenges around degrader specificity and adverse events
  • Tackling issues surrounding dosing, stability, biodistribution, tissue penetration, and more


The deadline for priority consideration is September 23, 2022.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


We hope you can join us for the 5 concurrent day-and-a-half conferences during each half of our 18th Annual Drug Discovery Chemistry event. Registering for this conference lets you also move back and forth among parallel programs to create your own agenda.


Opportunities for Participation:



For more details on the conference, please contact:

Tanuja Koppal, PhD

Senior Conference Director

Cambridge Healthtech Institute



For sponsorship information, please contact:

Kristin Skahan

Senior Business Development Manager

Cambridge Healthtech Institute

Phone: (+1) 781-972-5431