Cambridge Healthtech Institute’s 9th Annual

Degraders & Molecular Glues - Part 2

Pursuing Challenging Drug Targets, Exploring New Ligases, and Degradation Pathways

April 15-16, 2026

Bi-functional degraders like Proteolysis-targeting chimeras (PROTACs), monovalent degraders like molecular glues and other emerging degrader modalities are being used to hijack the ubiquitin-proteasome, lysosome, and autophagy systems for targeted protein degradation. They are seeking out previously “undruggable” targets for therapeutic intervention by exploring novel chemistries and chemical spaces and using innovative assays and screening tools to better understand and predict complex cellular interactions. This two-part conference on Degraders & Molecular Glues brings together experts in the field to discuss opportunities and challenges involved in pursuing targeted degradation and induced proximity as viable therapeutic strategies.

Coverage will likely include:

• Update on emerging PROTACs, molecular glues, and new degrader modalities and conjugates
• Structural and mechanistic characterization using innovative assays and platforms
• Finding new ligases, cellular pathways, and mechanisms for targeted degradation
• Emerging chemistries to induce proximity and degradation for pursuing new target space
• Pursuing extracellular as well as hard-to-drug intracellular targets for degradation
• Use of AI/ML to design novel degraders/glues and identify new drug targets
• Degradation of RNA, lipids, and other cellular macromolecules  

The deadline for priority consideration is September 30, 2025.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation:

• To submit a podium presentation, please click here.
• To become a sponsor, click here.
• To present a poster, click here.

For more details on the conference, please contact:
Tanuja Koppal, PhD
Senior Conference Director
Cambridge Healthtech Institute
Email: tkoppal@healthtech.com

For sponsorship information, please contact:
Kristin Skahan
Senior Business Development Manager
Cambridge Healthtech Institute
Phone: (+1) 781-972-5431
Email: kskahan@healthtech.com