2026 POSTER PRESENTATIONS

Preliminary List as of March 19, 2026

Almirall, S.A.
Discovery of Potent and Selective, VHL-Based STAT6 PROTACs for Oral Treatment of Type II Inflammatory Diseases

AlphaMa Biotechnology
The Development and Application of DNA-Encoded Cyclic Peptide Libraries

Anthem Preparatory Academy
Covalent Drug Discovery for Inhibition of Mitoptosis

Axxam SpA
A High-Throughput Screening and Triage Platform for Identifying PPI Disruptors in Cancer

Axxam SpA
Machine Learning–Guided De Novo Design of a Proprietary PPI Modulator Library

BioDuro
High-Throughput Peptide Screening for Radioligands by DNA Encoded Libraries

Biosensing Instrument
Label-Free Characterization of Binding Kinetics of Anti-HER1, Anti-HER2 and Anti-HER3 Therapeutic Antibodies in Whole Single Cells Using Surface Plasmon Resonance Microscopy (SPRM)

BIOVIA by Dassault Systèmes
Exploring Novel Cancer Therapeutics with Generative Design at OICR

Bruker
Unraveling PROTAC Mechanisms: from DEL Screening to Cellular Degradation Through Biophysical Profiling

Captor Therapeutics S.A.
Development of a First-in-Class MCL-1 Degrader: A Cardiosafe Therapeutic Strategy for AML Treatment

Captor Therapeutics S.A.
LiLis: Harnessing New E3 Ligases for Targeted Protein Degradation Platform

Carterra, Inc.
HT-SPR Screening and Kinetic Characterization of Small-Molecule Binders Using Carterra Vega™ and Comparison with AI Binding Predictions

Carterra, Inc.
Increasing DNA Encoded Library Screening Resolution Using HT-SPR

Carterra, Inc.
Massively Parallel SPR-Based Fragment Screening of Kinase Arrays

Cayman Chemical Company
Validation and Characterization of Anti-Citrulline Antibodies and Citrullinated Proteins

CellarisBio
A Cellular Target Engagement Atlas of 100+ Drug Targets Validated by MICRO-TAG Platform

CellarisBio
Cellular DNA-Encoded Library (DEL) Screening Coupled with MICRO-TAG® Real-Time Cellular Target Engagement Enables Discovery of Novel Therapeutics

CellarisBio
MICRO-TAG® Cell Target Engagement Redefines GPCR Drug Discovery with Functional Relevance

Chapman University
AI-Guided Discovery of Novel a7 Nicotinic Acetylcholine Receptor (nAChR) Positive Allosteric Modulators Using Iterative Generative Design

Chemspace LLC
Discovery, Design, and Delivery of New Inhibitors for NSP13 Through High-Performance Chemspace Platform

Chemspace LLC
Freedom Space 5.0: Enabling Diversity and Synthetic Feasibility in Billion-Scale Chemical Space

ChomiX Biotech Co., Ltd.
CMX-001: A First-in-Class, Irreversible FAP-Targeting Radiotherapeutic with Human Proof-of-Concept Enabled by the ChomiX Chemoproteomic Platform

Columbia University
Hyaline: Geometric Deep Learning for Accurate Prediction of G Protein-Coupled Receptor Activation States from Structure

Concept Life Sciences
Targeting the NLRP3 Inflammasome: Advancing Small Molecule Inhibitors for Inflammatory Disease Treatment

Cresset
An active Learning FEP Workflow to Identify the Most Promising Molecules to Make and Test

Dalriada Drug Discovery, Inc.
Discovering Ligands for Novel Pockets and “Hard-to-Drug” Targets with Live-Cell Data

Dalriada Drug Discovery, Inc.
SpiroQuest: Macrocycle Library, Novel Macrocycle Design and Virtual Library

DEL Source
Accelerating Covalent Drug Discovery Through Computational Design and Medicinal Chemistry with CovScan

DEL Source
Advancing Drug Discovery with DEL-Pilot and Integrated DEL-Source Workflows

Duke University
Characterization of the Role of GALE in Airway Mucin Biosynthesis

Edelris
Accelerating Molecular Glue Discovery Through Novel Chemical Space and ASMS Screening

Elixir Software Ltd.
Unified Scientific Workflows with iTraX™: Connecting Teams, Data and Decisions Across Drug Discovery

Enamine Ltd
Discovery of Novel BRD4-Targeting PROTAC Degraders Using Enamine’s E3 Ligase–Linker Conjugate Platform

Eurofins Discovery
Characterization of Next-Generation Obesity Therapeutics Using Preclinical and Translational Models

Eurofins Discovery
Comprehensive Analysis of Clinically Discontinued Compounds Using and In Vitro Secondary Pharmacology Panel to Predict Safety Liabilities

Eurofins Discovery
Discovery of WEE1 Degraders: Integrating Macrocyclic PROTAC Design and High-Throughput Molecular Glue Screening

Eurofins Discovery
Expediting GPCR Drug Discovery: Dual Strategy Combining Spectral Shift Screening and Coarse-Grained Molecular Dynamics for A2AR

Eurofins Discovery
Integrated High-Throughput Biochemical Binding and Cell-Based Targeted Protein Degradation Assay Platforms for STAT Degraders

Evotec
Bayesian Optimization-Driven Compound Selection for Direct-to-Biology Approaches in Drug Discovery

Fidabio
Small Molecule Interactions with Membrane Proteins Using Flow Induced Dispersion Analysis

FIMECS, Inc.
Discovery of Novel E3 Ligase Ligands for Targeted Protein Degraders with a Phenotypic-First Approach to Expand Degrader Landscape

Flatiron Institute
CyclicChamp: Heuristic Energy-Based Cyclic Peptide Design

Foghorn Therapeutics
Assessing Cellular Target Engagement with MICRO-TAG®: ARID1B as an “Undruggable" Case Study

Georgia Institute of Technology
Structure-Based Graph Neural Network for Zero-Shot Drug Similarity Prediction

Ginkgo Bioworks
ADME at Scale: High-Throughput Data Generation to Power AI-Enabled Drug Discovery

HitChem
Ligand-Based CRBN Molecular Glue Library: Design, Screening, and Application in Hit Discovery

Incyte Corporation
How Med Chem MET DMPK to Discover the First FDA Approved Selective c-Met Inhibitor Capmatinib

insitro
Electrophoretic Selections with DNA-Encoded Libraries Provide Training Sets with Massively High-Throughput Affinity Measurements

insitro
Programmed DNA-Encoded Library Synthesis: Overcoming Combinatorial Constraints to Enable Surgical Construction of Active Learning Training Sets

insitro
Quantitative Adapted Libraries: Making ML-Driven Lead Optimization a Reality

insitro
Rapid Design of Quantitative Adaptive Libraries (QALs) with an ML Enabled Web Application

insitro
Synthesis of Bivalent Programmed DNA-Encoded Libraries: Exploiting Avidity to Capture the Low-Affinity Gradient for Predictive Binding Models

IRBM S.p.A.
Electrophile-First Approach Enables Rapid Identification of ATP-Competitive Inhibitors of Werner Helicas

Kimia Therapeutics
ATLAS Breaks Data Scaling Barriers for Machine Learning via High-Throughput Synthesis and Screening

K-MEDI hub, Daegu-Gyeongbuk Medical Innovation Foundation
In Silico-Driven Discovery of Novel Senotherapeutic Leads for Managing Metabolic Disorders

K-MEDI hub, Daegu-Gyeongbuk Medical Innovation Foundation
Structural Diversity-Aware ADMET Data Curation and Validation for Federated Learning

LGC Standards USA
Designing Stable Isotope-Labelled Internal Standards that Behave Like the Analyte in LC–MS Analysis

Life Chemicals, Inc.
Novel Fragment Libraries for Drug Discovery

Life Chemicals, Inc.
Screening Compound Libraries for HTS and Lead Discovery Projects

MedChemica Ltd.
Patent Analysis -> Scaffold Hopping -> Improved ADMET Properties

Merck & Co., Inc.
Predicted Properties in Fragment-to-Lead Design

Midwestern University
Covalent Inhibitors for Treatment of Schizophrenia

Midwestern University
Modulating m6A Using FTO Inhibitors for Treatment of Neurological Disease States

MolPort
Selection of Functionalizable Ro3 Fragments from a 6M Compound Library to Support Fragment-Based Drug Discovery

National Institutes of Health, National Center for Advancing Translational Sciences
Development of TRAP1 Agonist 1685 to Modulate Mitochondrial-Lysosomal Crosstalk

National Institutes of Health, National Center for Advancing Translational Sciences
Identifying Small Molecules that Modulate Hypoxia-Inducible Factor Nuclear Translocation

National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism
Molecular Determinants of CB1 Receptor Binding and Function in the Alkyl Pyrazoline-Based Urea and Thiourea Series

Novalix
Comprehensive Biophysical Characterization of PROTAC Molecules Using Orthogonal Techniques

Novalix
Macrocycles as Novel PI4KIIIb Inhibitors to Tackle Human Rhinoviruses Infections

Nuvisan ICB GmbH
Direct-to-Biology for Accelerated Drug Discovery

o2h Discovery
Accelerating the Next Generation of Induced Proximity Therapeutics: Novel Assays for RiboTAC Drug Design and RNA-Binding Molecules

onepot.ai
Closing the “Make” Gap in Early Drug Discovery: Automated On-Demand Synthesis from a 3.4 Billion Compound Library

OpenEye, Cadence Molecular Sciences
ROCS X: An AI-Enabled 3D Search Method for Robust, Rapid Virtual Screening of Trillions

Pelago Bioscience
Integrating Degradation, Engagement, and Selectivity: CETSA® as a Framework for Degrader Validation

PeptiFinder Biotech, Inc.
mRNA Display - Revolutionizing Drug Discovery

Pharmacelera
Chemotype Discovery in Trillion Sized Chemical Spaces Using 3D Hydrophobicity Maps

Pohang University of Science and Technology (POSTECH)
Encoded Display of Chemical Libraries on Nanoparticles for Protein Ligand Discovery

Pohang University of Science and Technology (POSTECH)
Highly Ordered Clustering of TNFa and BAFF Ligand-Receptor-Intracellular Adaptor Complexes on a Lipid Membrane

Pohang University of Science and Technology (POSTECH)
In Situ Click Chemistry Screen of an On-Nanoparticle DNA-Encoded Library for the Development of Selective and Potent Peptoid Ligands

Portal Biotechnologies
Delivering Impermeable Probes and Tracers for Intracellular Measurement of Protein Degradation, Target Engagement, and Screening in Live Cells

Portal Biotechnologies
Enabling Live Cell Assays with a Silicon Membrane-Based Platform for Mechanical Delivery to Accelerate Early Drug Discovery

Promega Corporation
BRETSA: An Ultra-Sensitive, Broadly-Applicable BRET Method to Measure Target Engagement Through Protein Denaturation in Live Cells

Promega Corporation
De-Risking CRBN-Recruiting Degraders: Characterizing Neosubstrate Degradation Specificity and Selectivity

Promega Corporation
Innovative Bioluminescence Assays for Monitoring GPCR Dynamics: Advancing Therapeutic Strategies for Metabolic Disease

Promega Corporation
Real-Time Monitoring of Targeted Protein Degradation in Living Cells: Enabling Live-Cell Kinetic Analysis at Every Step

Qunova Computing, Inc.
A Quantum-Enhanced Framework for Modeling Protein–Ligand Binding Energies in Drug Discovery

Reaction Biology
Repurposing Kinase Inhibitors to Target Rare Cancers

RIKEN
Massive MD Simulations on Fugaku Reveal the LIMS-W Mechanism: A Novel Structural Basis for Designing Amyloid Disaggregators

Saint Louis University
Discovery of Novel GPR34 Chemical Probes Through Virtual Screening and In-Vitro Evaluation

SandboxAQ
Pharmacological Profiling of GPCRs: A Hybrid Machine Learning and Physics-Based Framework for Mechanism of Action Prediction

SandboxAQ
Scaling Binding Affinity Prediction with Physics-Augmented AI and Free Energy Calculations: Application to E3 Ligase Modulators

Sanford Burnham Prebys
Discovery and Development of Novel Autophagy Inhibiting ATG13 Degrading Compounds

Schrödinger, Inc.
Modeling of Bifunctional Degrader Ternary Complexes and Potency Optimization Using the Schrödinger Platform

SCIEX
Elevating Speed and Sensitivity: Integration of Acoustic Ejection with the Next Generation QTOF Mass Spectrometer

Scripps Research Institute
Chemical Proteomics Reveals Orthosteric Bias in Protein-Ligand Co-Folding Models

SEEDSUPPLY, Inc.
Binder2030: A Standardized Quantitative Binding Resource for Membrane Protein Drug Discovery

Seoul National University Hospital
A Deubiquitin-Dependent Stability Regulator Controls a Stress-Adaptation Factor via Direct Protein–Protein Interaction in PDAC

Seoul National University Hospital
Deubiquitinase-Dependent Stabilization of SMAD Signaling Drives Chemoresistance in KRAS-Mutant Pancreatic Cancer

Seoul National University Hospital
Structure-Guided Profiling of a Chaperone-Mediated Protein–Protein Interaction Associated with Immune-Regulatory Features in Pancreatic Cancer

Septerna, Inc.
Multimodal Machine Learning for GPCR Hit Identification: Integrating Million-Scale DEL and HTS Datasets for Billion-Compound Virtual Screening

Simulations Plus
Novel Descriptors and Models for More Accurate ADME and PK Predictions of Beyond Rule of Five Molecules

St. Jude Children's Research Hospital
LCK-Targeting Molecular Glues Overcome Resistance to Inhibitor-Based Therapy in T-Cell Acute Lymphoblastic Leukemia

Stanford University
A Robust Pipeline for De Novo Macrocyclic Peptide Discovery Using Deep Learning and High-Throughput Screening

Taylor University
Generative AI and Machine Learning–Driven Design of Novel MAO-B Inhibitors for Parkinson’s Disease

UF Scripps Institute for Biomedical Innovation and Technology
The Search for Molecular Glues and Non-Inhibitory E3 Ligands via On-Bead Ubiquitination Assay in OBOC DELs

University of California, Los Angeles
An Organometallic Chemistry Approach to Peptide Tricycles

University of California, Merced
Structure-Based Virtual Screening Reveals Novel Anti-Coccidioides Compounds

University of California, Riverside
Covalent Targeting of Histidine Residues

University of California, Riverside
Detection of Circulating Exosome-Associated EphA2 from Pancreatic Cancer Cells and Patient Serum Using Simple Western and ELISA

University of California, Riverside
His/Lys Covalent BAK Inhibitors as Neuroprotective Agents

University of California, Riverside
Histidine-Covalent Cyclic Aryl-Fluorosulfate Peptides Targeting KRAS Mutants

University of California, Riverside
In Silico Fragment-Based Mapping of N-Terminal Pockets in TCPTP to Guide Pharmacophore Design

University of California, Riverside
Novel Mcl-1 His and Lys Covalent Agents from a Fragment-Merging Approach

University of California, Riverside
Targeted Degradation of Pin1 by Molecular Crowbars

University of California, San Diego
A Degron Decoy System Co-Opts Pathological Seeding to Enable Clearance of Multimeric Alpha-Synuclein

University of California, San Francisco
Million-Scale Macrocycle Docking for Drug Discovery

University of California, San Francisco
Transparent Acceleration of Structure-Based Virtual Screening with ChemSTEP

University of California, Santa Cruz
High-Throughput Cyclic Peptide Screening Using DNA-Encoded Libraries

University of California, Santa Cruz
Rational Design and Conformational Analysis of CuAAC-Derived Heptamers: Biasing Beyond-Rule-of-5 Macrocycles for Passive Membrane Permeability

University of California, Santa Cruz
Real-Time NanoBRET Target Engagement Reveals Permeability-Activity Relationships in BET-Targeting Degraders

University of California, Santa Cruz
The Search for Pharmacological Control over the Circadian Clock

University of Chicago
CRANBERRY: A Coarse-Grained RNA Model that Folds Tetraloops De Novo

University of Massachusetts, Amherst
Subtyping Small-Molecule Binding Mode to Abelson Kinase Using Nanopore Tweezers: Resolution of Orthosteric, Allosteric, and Co-Binding Interactions

Vipergen
DELs in Cells – Nuclear DNA-Binding Protein Screening

Virginia Commonwealth University
Targeting Transcription Factor FOSL1 as a Therapeutic Strategy for Head and Neck Squamous Cell Carcinoma

Viva Biotech
Innovative Approaches to Peptide Drug Development: From Discovery to Commercial

WuXi AppTec, Inc.
Biophysical Method and Platform Development for Rapid High Throughput Screening and Hit Validation

WuXi AppTec, Inc.
DNA-Encoded Libraries and Display Technologies Empower Early Discovery of Peptide Drugs and Peptide-Based Delivery Tools

WuXi AppTec, Inc.
Targeted In Vitro Pharmacology for GIPR/GLP-1R/GCGR in Weight Loss and Type 2 Diabetes Therapy

WuXi AppTec, Inc.
Unleashing the Power of Spectral Shift Technology for Ultra-High-Throughput Binding Assays

Xeureka, Inc.
In Silico Mapping of Structural Anchors: Identifying Critical C-Beta and N-Me Sites in Cyclosporine A via Semi-Systematic Truncation

xFOREST Therapeutics Co., Ltd.
Discovery of Picomolar-Selective RNA-Targeted Small Molecules via MatrixFOREST Using RNA Focused Chemical Library

XtalPi
Prospective Discovery of Molecular Glue Degraders Using AI-Guided Chemical Space Design and Robotics-Controlled Automated Synthesis

Yale University
Discovery of Novel Bis-Arylamidines with Broad-Spectrum Activity Against Molds and Yeasts

Yale University
Drugging Fungal Group I Introns Reveals a New Pathway for Antifungal Therapy