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Cambridge Healthtech Institute’s 16th Annual

Protein-Protein Interactions

April 12-13, 2023


Cambridge Healthtech Institute's 16th Annual Protein-Protein Interactions conference covers medicinal, biophysical, and structural chemists’ progress in discovering or designing compounds to modulate ‘difficult-to-drug' disease targets. Usually the PPI target is an intracellular protein that is part of a complex with other proteins or nucleic acids. Many diseases are caused by complexes of proteins that come together or fall apart when they’re not supposed to. Typically PPIs lack structural grooves for small molecule drug candidates to fit within; usually the protein target isn’t an enzyme so there isn’t even a catalytic pocket for a small molecule to block. Join colleagues to learn about and discuss recent and more frequent success in addressing PPI targets. Hear about progress-enabling approaches such as fragment-based drug discovery (FBDD), covalent approaches, and deploying bigger yet cell-penetrable molecules such as macrocyclic peptides.


Coverage will likely include:


  • Case studies on intractable targets (e.g. KRAS, MCL family, c-myc family, p53, viral complexes, neurodegeneration targets)
  • Targeted covalent inhibitor approaches (especially non-cysteine targeting)
  • Fragment-based drug discovery (FBDD) successes against PPIs
  • Biophysical tools and other new technologies for identifying PPI modulators
  • Structure-based approaches, especially cryoEM 
  • Destroy what you can’t inhibit: targeted protein degradation (TPD) approaches and PPIs


The deadline for priority consideration is September 23, 2022.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


We hope you can join us for the 5 concurrent day-and-a-half conferences during each half of our 18th Annual Drug Discovery Chemistry event. Registering for this conference lets you also move back and forth among parallel programs to create your own agenda.


Opportunities for Participation:



For more details on the conference, please contact:

Anjani Shah, PhD

Senior Conference Director and Lead Content Director for Drug Discovery Chemistry

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252



For sponsorship information, please contact:

Kristin Skahan

Senior Business Development Manager

Cambridge Healthtech Institute

Phone: (+1) 781-972-5431