Cambridge Healthtech Institute’s Inaugural

Targeting Transcription Factors

Novel Approaches to Modulate Seemingly Undruggable Targets

APRIL 10, 2023 | 1:00PM-5:15PM PDT

Transcription factors are proteins with DNA-binding domains that are involved in transcribing DNA into RNA. They are key cell regulators and alterations in their structure, binding or activity are often found associated with many abnormalities in cellular function or disease. Transcription factors have been targeted in different ways, by modulating their binding, interactions, activity, or expression levels, to generate the desired biological outcomes. However, their lack of defined structure and binding pockets have made them somewhat “undruggable”. This symposium on Targeting Transcription Factors brings together scientists who are working on innovative chemistries and technologies to target different transcription factors for therapeutic intervention.