Cambridge Healthtech Institute’s 3rd Annual
Small-Molecule Discovery Technologies
Innovations in Fragment-Based Drug Discovery and Emerging Lead-Generation Tools
April 20-21, 2027
CHI’s Small-Molecule Discovery Technologies conference covers lead-generation approaches ranging from well-established fragment-based ligand design to newer medicinal chemistry advances such as covalent chemistry and direct-to-biology (D2B) applications. A focus will be on the technological innovations of the biophysical-based tools enabling small-molecule drug discovery against difficult-to-drug targets such as protein-protein interactions (PPIs). But classic small molecule enzyme-inhibitor discovery stories, reflecting the event’s medicinal chemistry roots, will also be included. The more detailed discovery stories of small molecules advancing against PPI targets will be covered in our companion Targeting Protein-Protein Interactions conference in the second half of Drug Discovery Chemistry. The back-to-back conferences keep you apprised of new biophysical approaches, innovative applications of well-established tools, and small-molecules showing medical promise. All while providing the chance to interact with leaders in the fields of medicinal and biophysical chemistry.
Coverage will likely include:
- Fragment-based drug discovery innovations, best-practices, and expanded applications
- Covalent fragments as tools for TPD and induced-proximity discovery
- Covalent inhibitor discovery
- Direct-to-Biology (D2B) applications to lead generation
- New methods related to, or uses of, biophysical tools (e.g., NMR, SPR, Mass Spectrometry, ASMS)
- Merging information from various hit finding strategies (FBDD, DEL, Structure-Based Drug Design, Machine Learning) for more efficient hit-to-lead steps or drug candidate selection
- Small molecule inhibitor, medicinal chemistry discovery stories
The deadline for priority consideration is October 5, 2026.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation:
- To submit a podium presentation, please click here.
- To become a sponsor, click here.
- To present a poster, click here.