2026 ARCHIVES

2026 Training Seminar* (In-Person Only)

*Premium Pricing or separate registration required

Cambridge Healthtech Institute Training Seminars offer real-life case studies, problems encountered, and solutions applied, along with extensive coverage of academic theory and background. Each training seminar offers a mix of formal lectures and interactive discussions and activities to maximize the learning experience. These training seminars are led by experienced instructors who will focus on content applicable to your current research and provide important guidance for those new to their fields.

Drug Discovery Chemistry’s Training Seminars will be offered IN-PERSON ONLY.

Monday, April 13, 2026 10:00 am - 5:15 pm

TS1: Drug Exposure at the Target: The Role of ADME and Pharmacokinetics

Detailed Agenda

This training seminar describes how pharmacokinetics (PK) affects drug exposure at the intended target. The seminar opens with a foundation of clinical PK including the determination of key PK parameters from Cp-time data. Course materials also cover common preclinical ADME assays that allow estimation of a compound’s human PK properties. The materials bridge the idea of a compound’s PK and its observed pharmacodynamic effects (PD) through coverage of PK/PD modeling. Various drug modalities (e.g., small molecules, antibodies, and peptides) illustrate the concepts of the course.

Erland Stevens, PhD, James G. Martin Professor, Department of Chemistry, Davidson College

Session 1:

Determining PK parameters from IV Cp-time data
Determining PK parameters from oral Cp-time data
ADME

Session 2:

Membrane permeability
Metabolic stability & intrinsic clearance
Plasma protein binding
Compartment models

Session 3:

Pre-formulation & formulation
PBPK
Drug modalities
PK/PD models

This course is designed for:

Scientists and researchers in drug discovery or development who want a stronger grasp of how PK and ADME data impact efficacy and safety.
Graduate students or postdocs in pharmacology, medicinal chemistry, or pharmaceutical sciences looking to build real-world context around their training.
Regulatory professionals seeking to better understand how PK data are generated and interpreted.
Project managers or non-specialists involved in cross-functional teams who need a working knowledge of PK to facilitate communication and strategy.

Why attend?

Understanding drug exposure is essential for developing successful therapies. This seminar bridges theoretical PK concepts with practical applications in preclinical and clinical development, helping attendees contribute more effectively to research and decision-making in their organizations.

INSTRUCTOR BIOGRAPHY:

Erland Stevens, PhD, James G. Martin Professor, Department of Chemistry, Davidson College

Erland Stevens is formally trained as a synthetic organic chemist, with a PhD from the Department of Chemistry at the University of Michigan at Ann Arbor. He specialized in nitrogen heterocycle synthetic methodology. After completing his postdoctoral research at The Scripps Research Institute in La Jolla, CA, he joined the chemistry faculty at Davidson College in Davidson, NC. In addition to teaching organic chemistry, he created an undergraduate medicinal chemistry course and later published a textbook, Medicinal Chemistry: The Modern Drug Discovery Process, with Pearson Education. He then created an online medicinal chemistry course, which has been continuously revised and publicly available for approximately 10 years. He subsequently worked with Novartis to create additional online materials that are used with employees for continuing education purposes. He maintains two YouTube channels - Chem Help ASAP and Inside Drug Discovery.

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