bRo5: Macrocyclics, Degraders, & More Icon

Cambridge Healthtech Institute’s 2nd Annual

bRo5: Macrocyclics, Degraders & More

Designing Drug-Like Large Molecules beyond the Rule of Five

April 12-13, 2023


A new challenge for discovery chemists is designing larger molecules such as macrocyclics, constrained peptides, or bifunctional degraders for targeted protein degradation (TPD) applications that are better able to combat difficult intracellular targets than small molecules, but that retain the favorable drug properties of small molecules (oral bioavailability, solubility, and cell permeability). In other words, going beyond Lipinski’s rule of five is becoming a more common endeavor. At Cambridge Healthtech Institute’s 2nd Annual bRo5 conference, join fellow medicinal, computational, and synthetic chemists to discuss success stories and survey the field to discuss strategies for addressing these newer ‘large small molecule’ drug modalities.


Coverage will likely include:


  • Examples of ‘successful’ bRo5 compounds 
  • Case studies on optimization of bi-functional degraders and macrocyclics
  • Devising rational design rules for bRo5 compounds 
  • Constrained peptide approaches
  • Peptidomimetic design strategies for oral delivery
  • Permeability tweaks, scaffolds, and prediction


The deadline for priority consideration is September 23, 2022.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


We hope you can join us for the 5 concurrent day-and-a-half conferences during each half of our 18th Annual Drug Discovery Chemistry event. Registering for this conference lets you also move back and forth among parallel programs to create your own agenda.


Opportunities for Participation:



For more details on the conference, please contact:

Anjani Shah, PhD

Senior Conference Director and Lead Content Director for Drug Discovery Chemistry

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252



For sponsorship information, please contact:

Kristin Skahan

Senior Business Development Manager

Cambridge Healthtech Institute

Phone: (+1) 781-972-5431