Cambridge Healthtech Institute’s 4th Annual

Targeting Transcription Factors & Regulators

Small Molecule and Peptide Drugs to Modulate TF Structure, Function & Interactions

April 13, 2026


Transcription factors (TFs) are proteins with DNA-binding domains that are involved in transcribing DNA into RNA. They are a subset of a larger group of intrinsically disordered proteins (IDPs) that lack defined structure and binding pockets and are inherently “difficult to drug”. Targeting transcription factors involves preventing their binding with the DNA sequence, disrupting their interactions with other proteins and co-factors, or modulating the proteins and epigenetic regulators that are involved with their structure and function. This conference on Targeting Transcription Factors & Regulators brings together scientists who are working on innovative chemistries and technologies to develop inhibitors and activators of transcription factor-driven pathways for therapeutic intervention.

Coverage will likely include:

  • Progress in targeting transcription factors like Myc, p53, STAT, TEAD, Nrf2, IKZF, RUNX, and more
  • Chemoproteomics and covalent strategies to develop inhibitors, degraders, and stabilizers of TFs
  • Utilizing innovative biophysical and structural technologies to understand TF biology
  • Emerging molecular glues, induced proximity modulators, and covalent degraders for targeting TFs
  • Computer-assisted drug design and modeling, new screening platforms for finding TF modulators
  • AI/ML and deep learning models to predict protein binding and interactions
  • Novel approaches using decoy molecules, synthetic transcription factors, antibodies, and more     

The deadline for priority consideration is September 30, 2025.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation:

For more details on the conference, please contact:
Tanuja Koppal, PhD
Senior Conference Director
Cambridge Healthtech Institute
Email: tkoppal@healthtech.com

For sponsorship information, please contact:
Kristin Skahan
Senior Business Development Manager
Cambridge Healthtech Institute
Phone: (+1) 781-972-5431
Email: kskahan@healthtech.com