Cambridge Healthtech Institute’s 8th Annual

DNA-Encoded Libraries

April 15-16, 2026


DNA-Encoded Libraries (DELs) are increasingly being used in the drug discovery industry to identify novel chemical matter with therapeutic potential. This lead generation approach uses combinatorial biology to synthesize chemical building blocks tagged with DNA, allowing protein targets to be screened against vast numbers of molecules more efficiently than traditional methods. While DEL technology expands the pool of potential hits, it also introduces the challenge of selecting the most viable drug candidates. The field is now pushing boundaries by applying DEL to more difficult targets, such as membrane proteins, and exploring advanced applications like discovering molecular glues and covalent binders. At Cambridge Healthtech Institute’s 8th Annual DNA-Encoded Libraries (DEL) conference, join experienced discovery chemists and DEL practitioners to hear about innovations, exchange best practices, and discuss practical challenges. 

Coverage will likely include:

  • Library design advances (covalent applications, use for fragment libraries)
  • Applying DEL for macrocyclic peptides and "larger" small molecules
  • Using DEL to discuss small molecules for complex targets (e.g., GPCRs, RNA)
  • DEL screening innovations (e.g., native environment ‘DEL in Cells’ and one-bead-one-compound)
  • Newer strategies for confirming DEL hits (e.g., Affinity Selection Mass Spectrometry)
  • Hit confirmation for On and Off –DNA synthesis
  • DEL for targeted protein degradation (TPD) strategies
  • Combining DEL & other HTS results
  • Beyond screening: DEL data for drug candidate selection
  • Incorporating AI into hit selection or to expand chemical space
  • Case studies of DEL-origin compounds progressing in drug development      

The deadline for priority consideration is September 30, 2025.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation:

For more details on the conference, please contact:
Anjani Shah, PhD
Senior Conference Director
Cambridge Healthtech Institute
(+1) 781-247-6252
Email: ashah@healthtech.com

For sponsorship information, please contact:
Kristin Skahan
Senior Business Development Manager
Cambridge Healthtech Institute
Phone: (+1) 781-972-5431
Email: kskahan@healthtech.com