DNA-Encoded Libraries | April 19-22, 2027 | San Diego, CA

DNA-Encoded Libraries

A Small-Molecule Lead-Generation Technology with Expanding Possibilities April 21-22, 2027

4/21/2027 - April 22, 2027 ALL TIMES PDT

Over the past decade DNA-encoded libraries (DEL) have become a core component of pharmaceutical companiesâ€™ hit-finding campaigns for new therapeutics. DEL technology is also moving beyond traditional drug lead generation and making its mark in all facets of small-molecule drug discovery, even in peptide discovery. Why is DEL becoming indelible? Join us at CHI's 9th Annual DNA-Encoded Libraries conference to discuss with pioneers and more recent practitioners in the DEL field, the latest DEL successes, newer applications and "nitty-gritty" DELT innovations.

Preliminary Agenda

DEL CASE STUDIES: COVALENT APPLICATIONS & MORE

Covalent Methods in DNA-Encoded Library (DEL) Drug Discovery

Photo of Elizabeth D'ambrosio, PhD, Investigator, DNA-Encoded Library Technology, GlaxoSmithKline , Investigator , DNA-Encoded Library Technology , GlaxoSmithKline — Elizabeth D'ambrosio, PhD, Investigator, DNA-Encoded Library Technology, GlaxoSmithKline , Investigator , DNA-Encoded Library Technology , GlaxoSmithKline

Progression of a Selective BCL2-A1 Inhibitor Identified from a DNA-Encoded Library (DEL) Screen

Photo of Kelly Craft, PhD, Senior Scientist I, Discovery Research, AbbVie Inc. , Senior Scientist I , Discovery Research , AbbVie Inc — Kelly Craft, PhD, Senior Scientist I, Discovery Research, AbbVie Inc. , Senior Scientist I , Discovery Research , AbbVie Inc

UsingÂ DEL to Overcome HomologÂ Selectivity Challenges: PGK1 & PGK2 Case Study

Photo of Srinivas Chamakuri, PhD, Assistant Professor, Pathology & Immunology, Baylor College of Medicine , Asst Prof , Pathology & Immunology , Baylor College of Medicine — Srinivas Chamakuri, PhD, Assistant Professor, Pathology & Immunology, Baylor College of Medicine , Asst Prof , Pathology & Immunology , Baylor College of Medicine

Uncovering Novel Allosteric Sites on WRN Helicase through Collaborative DEL and Fragment-Based Approaches

Photo of Sriram Tyagarajan, Associate Principal Scientist, Discovery Chemistry, Merck Sharp & Dohme LLC , Associate Principal Scientist , Discovery Chemistry , Merck Sharp & Dohme LLC — Sriram Tyagarajan, Associate Principal Scientist, Discovery Chemistry, Merck Sharp & Dohme LLC , Associate Principal Scientist , Discovery Chemistry , Merck Sharp & Dohme LLC

DEL & MOLECULAR GLUES (DEGRADING AND NON-DEGRADING)

Non-Degradative Protein Modulation with Rapamycin-Inspired Molecular Glue DELs

Photo of Sam Y. Hong, PhD, Senior Director, Platform, Rapafusyn Pharmaceuticals , Sr Dir Platform , Platform , Rapafusyn Pharmaceuticals — Sam Y. Hong, PhD, Senior Director, Platform, Rapafusyn Pharmaceuticals , Sr Dir Platform , Platform , Rapafusyn Pharmaceuticals

Discovery of Molecular Glues from an FKBP12-Focused DNA-Encoded Library

Photo of Trevor A. Zandi, PhD, Associate Research Scientist, Craig Crews Lab, Yale University , Associate Research Scientist , Craig Crews Lab , Yale University — Trevor A. Zandi, PhD, Associate Research Scientist, Craig Crews Lab, Yale University , Associate Research Scientist , Craig Crews Lab , Yale University

DEL Applications to Molecular Glue Discovery

Photo of Lucas Mastromatteo, Senior Scientist, Data Science, GSK , Data Scientist , GSK — Lucas Mastromatteo, Senior Scientist, Data Science, GSK , Data Scientist , GSK

DEL & E3 Ligase Discovery Case Studies

Photo of Christopher B. Phelps, PhD, Vice President and Head, Early Discovery, Nurix Therapeutics, Inc. , VP & Head Early Drug Discovery , Early Drug Discovery , Nurix Therapeutics Inc — Christopher B. Phelps, PhD, Vice President and Head, Early Discovery, Nurix Therapeutics, Inc. , VP & Head Early Drug Discovery , Early Drug Discovery , Nurix Therapeutics Inc

DEL INNOVATIONS

Magnetic Automation in Affinity and OBOC DEL Synthesis and Cellular Screening

Photo of Brian M. Paegel, PhD, Professor, Pharmaceuticals Sciences, University of California, Irvine , Professor , Pharmaceuticals Sciences , University of California, Irvine — Brian M. Paegel, PhD, Professor, Pharmaceuticals Sciences, University of California, Irvine , Professor , Pharmaceuticals Sciences , University of California, Irvine

Magnetic microparticle technology revolutionized genomic sample preparation automation; we are now leveraging these capabilities for automating the complex processes of DEL synthesis and cellular screening. Topics will include anion exchange on-DNA chemical synthesis technology development, magnetic microparticle engineering for multiplexed synthesis and bioactivity detection, and deployment of these technologies in whole-cell activity-based screening.

Building the Next Generation of DEL Datasets for AI

Photo of Timothy L. Foley, PhD, Senior Principal Scientist & Lab Head, DNA Encoded Library Selection & Pharmacology, Pfizer Global R&D Groton Labs , Lab Head, Associate Research Fellow , DNA Encoded Library Selection & Pharmacology , Pfizer Global R&D Groton Labs — Timothy L. Foley, PhD, Senior Principal Scientist & Lab Head, DNA Encoded Library Selection & Pharmacology, Pfizer Global R&D Groton Labs , Lab Head, Associate Research Fellow , DNA Encoded Library Selection & Pharmacology , Pfizer Global R&D Groton Labs

PLENARY SESSIONS

PLENARY KEYNOTE

PLENARY KEYNOTE

Photo of Gwenn Hansen, PhD, CSO, Nurix Therapeutics, Inc. , Chief Scientific Officer , Research , Nurix Therapeutics Inc — Gwenn Hansen, PhD, CSO, Nurix Therapeutics, Inc. , Chief Scientific Officer , Research , Nurix Therapeutics Inc

PLENARY PANEL: INSIGHTS FROM VENTURE CAPITALISTS

Panel Moderator:

PANEL DISCUSSION:
VC Insights on Drug Discovery Trends

Daniel A. Erlanson, PhD, Chief Innovation Officer, Frontier Medicines Corporation , Chief Innovation Officer , Frontier Medicines Corporation

Panelists:

James Edwards, PhD, Venture Partner, Samsara BioCapital , Venture Partner , Samsara BioCapital

Jamie Kasuboski, PhD, Partner, Luma Group , Partner , Luma Group

KT Moortgat, PhD, Managing Partner & Founder, Dalena Capital , Managing Partner & Founder , Dalena Capital

Sonia Setayesh, PhD, Partner, Civilization Ventures , Partner , Civilization Ventures

Chris Smith, PhD, CSO Partner Team, Curie.Bio , VP CSO Partner Team , Drug Discovery , Curie.Bio

Daniella Tedesco, Partner & Co-Founder, NextRound Philanthrophy , Co-Founder , NextRound Philanthrophy

For more details on the conference, please contact:
Anjani Shah, PhD
Senior Conference Director
Cambridge Healthtech Institute
(+1) 781-247-6252
Email: ashah@healthtech.com

For sponsorship information, please contact:
Kristin Skahan
Senior Business Development Manager
Cambridge Healthtech Institute
Phone: (+1) 781-972-5431
Email: kskahan@healthtech.com

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