Oral & Macrocyclic Peptides – Part 1
Advancing the Frontier of Peptide Therapeutics
4/20/2027 - April 21, 2027 ALL TIMES PDT
Cambridge Healthtech Institute's Oral & Macrocyclic Peptides conferences (parts 1 & 2) are among the few peptide therapeutics conferences devoted to chemistry. The cornerstone of this two-part meeting is oral and/or macrocyclic peptide design and discovery, reflecting the next generation of peptide therapeutics and this conference's claim to fame as the industry's first macrocyclic-focused conference. However, peptide chemistry with broad peptide drug discovery and development implications, such as those spurred by the flurry of GLP1-related peptide activity, and downstream peptide development, will also be considered because the industry's frontier of peptide chemistry is relatively new and the scientists as well as the molecules are advancing together. Join us for this recently expanded two-part program to share progress, challenges, and solutions among leading medicinal and drug development peptide chemists, who are often one and the same (unlike the case for small molecules).
Preliminary Agenda

Session Header

CYCLIC (MOSTLY) PEPTIDE DISCOVERY, DESIGN, OR OPTIMIZATION

High-Throughput Synthesis of Covalent and Non-Covalent Peptides to Screen Challenging Protein Targets 

Photo of Christian Heinis, PhD, Associate Professor, Lab of Therapeutic Proteins & Peptides, EPFL Lausanne , Assoc Prof , Lab of Therapeutic Proteins & Peptides , EPFL Lausanne
Christian Heinis, PhD, Associate Professor, Lab of Therapeutic Proteins & Peptides, EPFL Lausanne , Assoc Prof , Lab of Therapeutic Proteins & Peptides , EPFL Lausanne

Tetra Peptides

Photo of Krishna Kumar, PhD, Robinson Professor of Chemistry, Tufts University , Robinson Professor , Chemistry , Tufts University
Krishna Kumar, PhD, Robinson Professor of Chemistry, Tufts University , Robinson Professor , Chemistry , Tufts University

Conformational Control for Property Enhancement of Macrocycles

Photo of Felix Hausch, PhD, Professor Biochemistry, Structure Based Drug Discovery, Technical University of Darmstadt , Prof Biochemistry , Structure Based Drug Discovery , Technical Univ of Darmstadt
Felix Hausch, PhD, Professor Biochemistry, Structure Based Drug Discovery, Technical University of Darmstadt , Prof Biochemistry , Structure Based Drug Discovery , Technical Univ of Darmstadt

Bead-Based mRNA Display for Macrocyclic Libraries

Photo of Brian M. Paegel, PhD, Professor, Pharmaceuticals Sciences, University of California, Irvine , Professor , Pharmaceuticals Sciences , University of California, Irvine
Brian M. Paegel, PhD, Professor, Pharmaceuticals Sciences, University of California, Irvine , Professor , Pharmaceuticals Sciences , University of California, Irvine

Cyclic Peptide Inhibitor Discovery by Coupling DNA-Encoded Cyclic Peptide Libraries with an AI-Based Generative Model

Photo of Xiaojie Bruce Lu, PhD, Professor & Principal Investigator, Chemical Biology Research Center, Chinese Academy of Sciences , Prof & Principal Investigator , Chemical Biology Research Ctr , SIMM, CAS
Xiaojie Bruce Lu, PhD, Professor & Principal Investigator, Chemical Biology Research Center, Chinese Academy of Sciences , Prof & Principal Investigator , Chemical Biology Research Ctr , SIMM, CAS

DNA-Encoded Peptide Libraries

Photo of Valerie Waser , Postdoctoral Fellow , EPFL
Valerie Waser , Postdoctoral Fellow , EPFL

MACROCYCLIC INHIBITORS

Novel Macrocyclic Molecular Glue Modulators of STAT6 with Differentiated Pharmacology

Photo of Rick Ewing, PhD, Vice President and Head of Chemistry, Rapafusyn Pharmaceuticals , Vice President , Chemistry , Rapafusyn Pharmaceuticals
Rick Ewing, PhD, Vice President and Head of Chemistry, Rapafusyn Pharmaceuticals , Vice President , Chemistry , Rapafusyn Pharmaceuticals

Drugging Cyclin A/B Protein–Protein Interactions with Orally Bioavailable Macrocycles: From Structure-Guided Design to Clinical Translation

Photo of Peadar Cremin, PhD, Executive Director & Head of DMPK, Clinical Pharmacology & Toxicology, Circle Pharma Inc. , Executive Director & Head of DMPK , Clinical Pharmacology & Toxicology , Circle Pharma Inc
Peadar Cremin, PhD, Executive Director & Head of DMPK, Clinical Pharmacology & Toxicology, Circle Pharma Inc. , Executive Director & Head of DMPK , Clinical Pharmacology & Toxicology , Circle Pharma Inc

PLENARY

PLENARY KEYNOTE

The Druggable Transcriptome: From RNA Recognition to Precision Medicines

Matthew D. Disney, PhD, Institute Professor & Chair, UF Scripps Institute for Biomedical Innovation & Technology , Professor , Chemistry , Scripps Research Institute


For more details on the conference, please contact:
Anjani Shah, PhD
Senior Conference Director
Cambridge Healthtech Institute
(+1) 781-247-6252
Email: ashah@healthtech.com

For sponsorship information, please contact:
Kristin Skahan
Senior Business Development Manager
Cambridge Healthtech Institute
Phone: (+1) 781-972-5431
Email: kskahan@healthtech.com


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APRIL 19

Covalent & Induced Proximity-Based Therapies

RNA-Modulating Small Molecule Drugs

Generative AI for Drug Discovery

training seminars

View In-Person Short Courses

APRIL 20 - 21

Degraders & Molecular Glues - Part 1

Small Molecule Discovery Technologies

AI/ML for Early Drug Discovery - Part 1

Linker & Conjugation Chemistries

Peptides

APRIL 21 - 22

Degraders & Molecular Glues - Part 2

Protein-Protein Interactions / Difficult Targets

AI/ML for Early Drug Discovery - Part 2

DNA-Encoded Libraries

GLP1 & Oral Peptides


Drug Discovery Chemsitry Europe

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