Cambridge Healthtech Institute’s 19th Annual

Targeting Protein-Protein Interactions

Medicinal Chemistry Progress against Intractable Targets

April 15-16, 2026


Cambridge Healthtech Institute’s Targeting Protein-Protein Interactions conference focuses on discovery of therapeutic agents that inhibit or disrupt protein-protein interactions (PPIs) that stay together longer than they should, or stabilize molecular complexes that fall apart too easily. PPIs are harder to target by small molecules than are traditional intracellular enzymatic drug targets because PPI sites are usually ‘flat’, making it hard for small molecules to gain a foothold. Thanks to advances in detecting ligand-target binding, such as biophysical methods and newer lead-generation approaches such as DNA-encoded libraries (DEL), fragment-based lead design (FBLD), and covalent-based tools, a few drug candidates against PPIs have reached the market in the past decade and many are progressing in clinical trials. Join us to hear how scientists are discovering and designing small molecules or larger and beyond-rule-of-five (bRo5) molecules such as macrocyclic peptides, to disrupt or stabilize medically relevant protein complexes, especially intracellular PPIs. 

Coverage will likely include:

  • Progress against difficult (PPI) targets e.g. Ras proteins, other signaling complexes, and transcription or translation complexes
  • Deploying bigger (bRo5) yet cell-penetrable molecules such as macrocyclic peptides
  • Discovery of PPI stabilizers and glues (the non-degrading type)
  • Case studies on targeting protein complexes in cancer, CNS, and immunology-related diseases 

The deadline for priority consideration is September 30, 2025.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation:

For more details on the conference, please contact:
Anjani Shah, PhD
Senior Conference Director
Cambridge Healthtech Institute
(+1) 781-247-6252
Email: ashah@healthtech.com

For sponsorship information, please contact:
Kristin Skahan
Senior Business Development Manager
Cambridge Healthtech Institute
Phone: (+1) 781-972-5431
Email: kskahan@healthtech.com