Cambridge Healthtech Institute’s Inaugural

Degraders & Molecular Glues: Beyond Oncology

Designing and Optimizing PROTACs and Glue Modalities for Diverse Therapeutic Indications

April 14, 2025

Protein degraders and molecular glues are being developed to disrupt protein-protein interactions and to hijack the ubiquitin-proteasome, lysosome, and autophagy systems for targeted protein degradation. While most of the hetero-bifunctional degraders like proteolysis-targeting chimeras (PROTACs) and monovalent degraders like molecular glues are being used to target cancer, there are some headwinds driving non-oncology indications as well. This inaugural symposium that focuses on applications of Degraders & Molecular Glues: Beyond Oncology will be followed by a two-part conference on Degraders & Molecular Glues which emphasizes the growing use of targeted protein degradation and induced proximity as a new therapeutic approach.